Large, three-generation human families reveal post-zygotic mosaicism and variability in germline mutation accumulation

Large, three-generation human families reveal post-zygotic mosaicism and variability in germline mutation accumulation

The number of de novo mutations (DNMs) found in an offspring's genome increases with both paternal and maternal age. But does the rate of mutation accumulation in human gametes differ across families? Using sequencing data from 33 large, three-generation CEPH families, we observed significant v...

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Bibliographic Details
Main Authors: Thomas A Sasani, Brent S Pedersen, Ziyue Gao, Lisa Baird, Molly Przeworski, Lynn B Jorde, Aaron R Quinlan
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-09-01
Series:eLife
Subjects:
de novo mutation
germline mutation
post-zygotic mutation
mosaicism
Online Access:https://elifesciences.org/articles/46922

Internet

https://elifesciences.org/articles/46922

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