TRAF6 mediates IL-1β/LPS-induced suppression of TGF-β signaling through its interaction with the type III TGF-β receptor.

TRAF6 mediates IL-1β/LPS-induced suppression of TGF-β signaling through its interaction with the type III TGF-β receptor.

Transforming growth factor-β1 (TGF-β1) is an important anti-inflammatory cytokine that modulates and resolves inflammatory responses. Recent studies have demonstrated that inflammation enhances neoplastic risk and potentiates tumor progression. In the evolution of cancer, pro-inflammatory cytokines...

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Bibliographic Details
Main Authors: Seunghwan Lim, Eunjin Bae, Hae-Suk Kim, Tae-Aug Kim, Kyunghee Byun, Byungchul Kim, Suntaek Hong, Jong Pil Im, Chohee Yun, Bona Lee, Bonghee Lee, Seok Hee Park, John Letterio, Seong-Jin Kim
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3299683?pdf=render

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http://europepmc.org/articles/PMC3299683?pdf=render

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