Differential effects of β-catenin and NF-κB interplay in the regulation of cell proliferation, inflammation and tumorigenesis in response to bacterial infection.

Differential effects of β-catenin and NF-κB interplay in the regulation of cell proliferation, inflammation and tumorigenesis in response to bacterial infection.

Both β-catenin and NF-κB have been implicated in our laboratory as candidate factors in driving proliferation in an in vivo model of Citrobacter rodentium (CR)-induced colonic crypt hyper-proliferation and hyperplasia. Herein, we test the hypothesis that β-catenin and not necessarily NF-κB regulates...

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Bibliographic Details
Main Authors: Parthasarathy Chandrakesan, Laxmi Uma Maheswar Rao Jakkula, Ishfaq Ahmed, Badal Roy, Shrikant Anant, Shahid Umar
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3836902?pdf=render

Internet

http://europepmc.org/articles/PMC3836902?pdf=render

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