Challenging the Drug-Likeness Dogma for New Drug Discovery in Tuberculosis

Challenging the Drug-Likeness Dogma for New Drug Discovery in Tuberculosis

The emergence of multi- and extensively drug resistant tuberculosis worldwide poses a great threat to human health and highlight the need to discover and develop new, effective and inexpensive antituberculosis agents. High-throughput screening assays against well-validated drug targets and structure...

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Bibliographic Details
Main Authors: Diana Machado, Miriam Girardini, Miguel Viveiros, Marco Pieroni
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Microbiology
Subjects:
efflux inhibitors
lipophilicity
medicinal chemistry
proton motive force
rule of five
tuberculosis
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2018.01367/full

Internet

https://www.frontiersin.org/article/10.3389/fmicb.2018.01367/full

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