Increased generation of Foxp3+ regulatory T cells by manipulating antigen presentation in the thymus

Increased generation of Foxp3+ regulatory T cells by manipulating antigen presentation in the thymus

The degree of Treg self-antigen reactivity varies across experimental systems. Here the authors develop a new model of skin autoimmunity and show that the size of tissue-specific Treg pool in the thymus depends on AIRE, the availability of the tissue antigen, and its presentation by dendritic cells.

Bibliographic Details
Main Authors: Jiqiang Lin, Lu Yang, Hernandez Moura Silva, Alissa Trzeciak, Yongwon Choi, Susan R. Schwab, Michael L. Dustin, Juan J. Lafaille
Format: Article
Language:English
Published: Nature Publishing Group 2016-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms10562

Internet

https://doi.org/10.1038/ncomms10562

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