ORMDL3 and Asthma: Linking Sphingolipid Regulation to Altered T Cell Function

ORMDL3 and Asthma: Linking Sphingolipid Regulation to Altered T Cell Function

Orosomucoid like 3 (ORMDL3) encodes an ER-resident transmembrane protein that regulates the activity of serine palmitoyltransferase (SPT), the first and rate-limiting enzyme for sphingolipid biosynthesis in cells. A decade ago, several genome wide association studies revealed single nucleotide polym...

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Bibliographic Details
Main Authors: Christopher R. Luthers, Teresa M. Dunn, Andrew L. Snow
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Immunology
Subjects:
asthma
orosomucoid like sphingolipid biosynthesis regulator 3
T cell
sphingolipids
allergic inflammation
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.597945/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2020.597945/full

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