Lung-derived HMGB1 is detrimental for vascular remodeling of metabolically imbalanced arterial macrophages

Lung-derived HMGB1 is detrimental for vascular remodeling of metabolically imbalanced arterial macrophages

Lung damage increases abdominal aortic aneurysm (AAA) incidence, but the mechanism was unclear. Here, the authors show that injured lungs leak HMGB1, increasing RIPK3 expression in arterial macrophages that subsequently alters mitochondrial function, leading to MMP12 expression and AAA development.

Bibliographic Details
Main Authors: Ludovic Boytard, Tarik Hadi, Michele Silvestro, Hengdong Qu, Andrew Kumpfbeck, Rayan Sleiman, Kissinger Hyppolite Fils, Dornazsadat Alebrahim, Francesco Boccalatte, Matthias Kugler, Annanina Corsica, Bruce E. Gelb, Glenn Jacobowitz, George Miller, Chiara Bellini, Jessica Oakes, Jean-Sébastien Silvestre, Lior Zangi, Bhama Ramkhelawon
Format: Article
Language:English
Published: Nature Publishing Group 2020-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-18088-2

Internet

https://doi.org/10.1038/s41467-020-18088-2

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