Intrastriatal inhibition of aromatic amino acid decarboxylase prevents l-DOPA-induced dyskinesia: A bilateral reverse in vivo microdialysis study in 6-hydroxydopamine lesioned rats

Intrastriatal inhibition of aromatic amino acid decarboxylase prevents l-DOPA-induced dyskinesia: A bilateral reverse in vivo microdialysis study in 6-hydroxydopamine lesioned rats

l-3,4-dihydroxyphenylalanine (l-DOPA)-induced dyskinesia consists of involuntary choreiform and dystonic movements. Here we report whether intrastriatal l-DOPA itself is able to trigger dyskinetic behavior and which role the neurotransmitter dopamine (DA) and its metabolites play.Intrastriatal l-DOP...

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Bibliographic Details
Main Authors: Kerstin Buck, Boris Ferger
Format: Article
Language:English
Published: Elsevier 2008-02-01
Series:Neurobiology of Disease
Subjects:
Dyskinesia
6-Hydroxydopamine
In vivo microdialysis
l-DOPA
Parkinson’s disease
Dopamine
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996107001994

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http://www.sciencedirect.com/science/article/pii/S0969996107001994

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