Membrane-bound catechol-O-methyl transferase in cortical neurons and glial cells is intracellularly oriented

Membrane-bound catechol-O-methyl transferase in cortical neurons and glial cells is intracellularly oriented

Catechol-O-methyl transferase (COMT) is involved in the inactivation of dopamine in brain regions in which the dopamine transporter (DAT1) is sparsely expressed. The membrane-bound isoform of COMT (MB-COMT) is the predominantly expressed form in the mammalian central nervous system (CNS). It has bee...

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Bibliographic Details
Main Authors: Björn H Schott, Renato Frischknecht, Grazyna eDebska-Vielhaber, Nora John, Gusalija Behnisch, Emrah eDüzel, Eckart D Gundelfinger, Constanze I Seidenbecher
Format: Article
Language:English
Published: Frontiers Media S.A. 2010-10-01
Series:Frontiers in Psychiatry
Subjects:
Dopamine
membrane
neuronal cell culture
catechol-O-methyl transferase
immnunocytochemistry
Online Access:http://journal.frontiersin.org/Journal/10.3389/fpsyt.2010.00142/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fpsyt.2010.00142/full

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