Cocrystal of Apixaban–Quercetin: Improving Solubility and Bioavailability of Drug Combination of Two Poorly Soluble Drugs

Cocrystal of Apixaban–Quercetin: Improving Solubility and Bioavailability of Drug Combination of Two Poorly Soluble Drugs

Drug combinations have been the hotspot of the pharmaceutical industry, but the promising applications are limited by the unmet solubility and low bioavailability. In this work, novel cocrystals, consisting of two antithrombotic drugs with poor solubility and low bioavailability in vivo, namely, api...

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Bibliographic Details
Main Authors: Li Zhang, Dewen Kong, Hongjuan Wang, Lingtai Jiao, Xiaoyue Zhao, Junke Song, Dezhi Yang, Haiguang Yang, Shiying Yang, Guanhua Du, Yang Lu
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Molecules
Subjects:
drug–drug cocrystal
apixaban
quercetin
solubility
bioavailability
Online Access:https://www.mdpi.com/1420-3049/26/9/2677

Internet

https://www.mdpi.com/1420-3049/26/9/2677

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