Enhanced anticancer effect of doxorubicin by TPGS-coated liposomes with Bcl-2 siRNA-corona for dual suppression of drug resistance

Enhanced anticancer effect of doxorubicin by TPGS-coated liposomes with Bcl-2 siRNA-corona for dual suppression of drug resistance

Multiple drug resistance (MDR) is a tough problem in developing hepatocellular carcinoma (HCC) therapy. Here, we developed TPGS-coated cationic liposomes with Bcl-2 siRNA corona to load doxorubicin (Dox) i.e., Bcl-2 siRNA/Dox-TPGS-LPs, to enhance anticancer effect of Dox in HCC-MDR. TPGS i.e., d-α-t...

Full description

Bibliographic Details
Main Authors: Yinghuan Li, Xi Tan, Xuhan Liu, Lingyan Liu, Yan Fang, Rong Rao, Yuanyuan Ren, Xiangliang Yang, Wei Liu
Format: Article
Language:English
Published: Elsevier 2020-09-01
Series:Asian Journal of Pharmaceutical Sciences
Subjects:
Multiple drug resistance (MDR)
TPGS
siRNA-corona
Liposomes
P-glycoprotein (P-gp)
Bcl-2
Online Access:http://www.sciencedirect.com/science/article/pii/S1818087619300832

Internet

http://www.sciencedirect.com/science/article/pii/S1818087619300832

Similar Items