In vivo N-Terminomics Highlights Novel Functions of ADAMTS2 and ADAMTS14 in Skin Collagen Matrix Building

In vivo N-Terminomics Highlights Novel Functions of ADAMTS2 and ADAMTS14 in Skin Collagen Matrix Building

A disintegrin and metalloproteinase with thrombospondin type I motif (ADAMTS)2 and ADAMTS14 were originally known for their ability to cleave the aminopropeptides of fibrillar collagens. Previous work using N-terminomic approach (N-TAILS) in vitro led to the identification of new substrates, includi...

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Bibliographic Details
Main Authors: Cédric Leduc, Laura Dupont, Loïc Joannes, Christine Monseur, Dominique Baiwir, Gabriel Mazzucchelli, Christophe Deroanne, Alain Colige, Mourad Bekhouche
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Molecular Biosciences
Subjects:
ADAMTS
collagen
Ehlers-Danlos Syndrome (EDS)
degradomics
TAILS
N-Terminomics
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2021.643178/full

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https://www.frontiersin.org/articles/10.3389/fmolb.2021.643178/full

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