Cortical bone maturation in mice requires SOCS3 suppression of gp130/STAT3 signalling in osteocytes

Cortical bone maturation in mice requires SOCS3 suppression of gp130/STAT3 signalling in osteocytes

Bone strength is determined by its dense cortical shell, generated by unknown mechanisms. Here we use the Dmp1Cre:Socs3f/f mouse, with delayed cortical bone consolidation, to characterise cortical maturation and identify control signals. We show that cortical maturation requires a reduction in corti...

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Bibliographic Details
Main Authors: Emma C Walker, Kim Truong, Narelle E McGregor, Ingrid J Poulton, Tsuyoshi Isojima, Jonathan H Gooi, T John Martin, Natalie A Sims
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-05-01
Series:eLife
Subjects:
bone
development
osteocyte
cytokine
cortical bone
Online Access:https://elifesciences.org/articles/56666

Internet

https://elifesciences.org/articles/56666

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