The Deubiquitinating Enzyme USP20 Regulates the TNFα-Induced NF-κB Signaling Pathway through Stabilization of p62

The Deubiquitinating Enzyme USP20 Regulates the TNFα-Induced NF-κB Signaling Pathway through Stabilization of p62

p62/sequestosome-1 is a scaffolding protein involved in diverse cellular processes such as autophagy, oxidative stress, cell survival and death. It has been identified to interact with atypical protein kinase Cs (aPKCs), linking these kinases to NF-κB activation by tumor necrosis factor α (TNFα). Th...

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Bibliographic Details
Main Authors: Jihoon Ha, Minbeom Kim, Dongyeob Seo, Jin Seok Park, Jaewon Lee, Jinjoo Lee, Seok Hee Park
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:International Journal of Molecular Sciences
Subjects:
ubiquitin-specific protease 20
p62
tumor necrosis factor α
nuclear factor-κB
cell survival
apoptosis
Online Access:https://www.mdpi.com/1422-0067/21/9/3116

Internet

https://www.mdpi.com/1422-0067/21/9/3116

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