A human single-chain Fv intrabody preferentially targets amino-terminal huntingtin fragments in striatal models of Huntington's disease

A human single-chain Fv intrabody preferentially targets amino-terminal huntingtin fragments in striatal models of Huntington's disease

Amino-terminal fragments of huntingtin (htt) appear to result from proteolytic processing of the full-length protein in Huntington's disease (HD), and fragments containing pathological expansions of polyglutamine elicit toxicity in model systems. Such fragments are sequestered into insoluble ag...

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Bibliographic Details
Main Authors: Todd W. Miller, Chun Zhou, Silvia Gines, Marcy E. MacDonald, Nicholas D. Mazarakis, Gillian P. Bates, James S. Huston, Anne Messer
Format: Article
Language:English
Published: Elsevier 2005-06-01
Series:Neurobiology of Disease
Subjects:
Polyglutamine
Aggregation
Intrabody
Huntington's disease
Huntingtin
Antibody
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996104002773

Internet

http://www.sciencedirect.com/science/article/pii/S0969996104002773

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