Phosphorus Pentachloride Promoted gem-Dichlorination of 2′- and 3′-Deoxynucleosides

Phosphorus Pentachloride Promoted gem-Dichlorination of 2′- and 3′-Deoxynucleosides

Halogen substitution at various positions of canonical nucleosides has generated a number of bioactive structural variants. Herein, the synthesis of two unique series of sugar modified nucleosides bearing a gem-dichloro group is presented. The synthetic plan entails the controlled addition of phosph...

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Bibliographic Details
Main Authors: Fabio da Paixao Soares, Elisabetta Groaz, Piet Herdewijn
Format: Article
Language:English
Published: MDPI AG 2018-06-01
Series:Molecules
Subjects:
gem-dichlorination
modified nucleosides
halogenated nucleosides
phosphorus pentachloride
Online Access:http://www.mdpi.com/1420-3049/23/6/1457

Internet

http://www.mdpi.com/1420-3049/23/6/1457

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