Transcriptional profiling reveals a subset of human breast tumors that retain wt TP53 but display mutant p53‐associated features

Transcriptional profiling reveals a subset of human breast tumors that retain wt TP53 but display mutant p53‐associated features

TP53 gene mutations are very common in human cancer. While such mutations abrogate the tumor suppressive activities of the wild‐type (wt) p53 protein, some of them also endow the mutant (mut) protein with oncogenic gain of function (GOF), facilitating cancer progression. Yet, p53 may acquire altered...

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Bibliographic Details
Main Authors: Gal Benor, Garold Fuks, Suet‐Feung Chin, Oscar M. Rueda, Saptaparna Mukherjee, Sharathchandra Arandkar, Yael Aylon, Carlos Caldas, Eytan Domany, Moshe Oren
Format: Article
Language:English
Published: Wiley 2020-08-01
Series:Molecular Oncology
Subjects:
breast cancer
machine learning
METABRIC
p53 gain of function
pseudomutant p53
Online Access:https://doi.org/10.1002/1878-0261.12736

Internet

https://doi.org/10.1002/1878-0261.12736

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