Human umbilical cord-derived mesenchymal stem cells improve the function of liver in rats with acute-on-chronic liver failure via downregulating Notch and Stat1/Stat3 signaling

Human umbilical cord-derived mesenchymal stem cells improve the function of liver in rats with acute-on-chronic liver failure via downregulating Notch and Stat1/Stat3 signaling

Abstract Background Effective treatments for acute-on-chronic liver failure (ACLF) are lacking. Human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) have been applied in tissue regeneration and repair, acting through paracrine effects, cell fusion, and actual transdifferentiation. The pres...

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Bibliographic Details
Main Authors: Yulin He, Xingrong Guo, Tingyu Lan, Jianbo Xia, Jinsong Wang, Bei Li, Chunyan Peng, Yue Chen, Xiang Hu, Zhongji Meng
Format: Article
Language:English
Published: BMC 2021-07-01
Series:Stem Cell Research & Therapy
Subjects:
Liver fibrosis
Liver injury
ACLF
hUC-MSCs
Paracrine
Notch
Online Access:https://doi.org/10.1186/s13287-021-02468-6

Internet

https://doi.org/10.1186/s13287-021-02468-6

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