Maladaptive synaptic plasticity in L-DOPA-induced dyskinesia
The emergence of L-DOPA-induced dyskinesia (LID) in patients with Parkinson disease (PD) could be due to maladaptive plasticity of corticostriatal synapses in response to L-DOPA treatment. A series of recent studies has revealed that LID is associated with marked morphological plasticity of striatal...
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doaj-0e4656d49a7b49f7aabd318f2e8b69512020-11-25T00:17:08ZengFrontiers Media S.A.Frontiers in Neural Circuits1662-51102016-12-011010.3389/fncir.2016.00105191684Maladaptive synaptic plasticity in L-DOPA-induced dyskinesiaQiang Wang0Wangming Zhang1Southern Medical UniversitySouthern Medical UniversityThe emergence of L-DOPA-induced dyskinesia (LID) in patients with Parkinson disease (PD) could be due to maladaptive plasticity of corticostriatal synapses in response to L-DOPA treatment. A series of recent studies has revealed that LID is associated with marked morphological plasticity of striatal dendritic spines, particularly cell type-specific structural plasticity of medium spiny neurons (MSNs) in the striatum. In addition, evidence demonstrating the occurrence of plastic adaptations, including aberrant morphological and functional features, in multiple components of cortico-basal ganglionic circuitry, such as primary motor cortex (M1) and basal ganglia (BG) output nuclei. These adaptations have been implicated in the pathophysiology of LID. Here, we briefly review recent studies that have addressed maladaptive plastic changes within the cortico-BG loop in dyskinetic animal models of PD and patients with PD.http://journal.frontiersin.org/Journal/10.3389/fncir.2016.00105/fullBasal GangliaDopamineMotor CortexParkinson's diseasesynaptic plasticity |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Qiang Wang Wangming Zhang |
spellingShingle |
Qiang Wang Wangming Zhang Maladaptive synaptic plasticity in L-DOPA-induced dyskinesia Frontiers in Neural Circuits Basal Ganglia Dopamine Motor Cortex Parkinson's disease synaptic plasticity |
author_facet |
Qiang Wang Wangming Zhang |
author_sort |
Qiang Wang |
title |
Maladaptive synaptic plasticity in L-DOPA-induced dyskinesia |
title_short |
Maladaptive synaptic plasticity in L-DOPA-induced dyskinesia |
title_full |
Maladaptive synaptic plasticity in L-DOPA-induced dyskinesia |
title_fullStr |
Maladaptive synaptic plasticity in L-DOPA-induced dyskinesia |
title_full_unstemmed |
Maladaptive synaptic plasticity in L-DOPA-induced dyskinesia |
title_sort |
maladaptive synaptic plasticity in l-dopa-induced dyskinesia |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Neural Circuits |
issn |
1662-5110 |
publishDate |
2016-12-01 |
description |
The emergence of L-DOPA-induced dyskinesia (LID) in patients with Parkinson disease (PD) could be due to maladaptive plasticity of corticostriatal synapses in response to L-DOPA treatment. A series of recent studies has revealed that LID is associated with marked morphological plasticity of striatal dendritic spines, particularly cell type-specific structural plasticity of medium spiny neurons (MSNs) in the striatum. In addition, evidence demonstrating the occurrence of plastic adaptations, including aberrant morphological and functional features, in multiple components of cortico-basal ganglionic circuitry, such as primary motor cortex (M1) and basal ganglia (BG) output nuclei. These adaptations have been implicated in the pathophysiology of LID. Here, we briefly review recent studies that have addressed maladaptive plastic changes within the cortico-BG loop in dyskinetic animal models of PD and patients with PD. |
topic |
Basal Ganglia Dopamine Motor Cortex Parkinson's disease synaptic plasticity |
url |
http://journal.frontiersin.org/Journal/10.3389/fncir.2016.00105/full |
work_keys_str_mv |
AT qiangwang maladaptivesynapticplasticityinldopainduceddyskinesia AT wangmingzhang maladaptivesynapticplasticityinldopainduceddyskinesia |
_version_ |
1725380830362075136 |