Comparison of microsatellite instability detection by immunohistochemistry and molecular techniques in colorectal and endometrial cancer

Abstract DNA mismatch repair deficiency (dMMR) testing is crucial for diagnosing Lynch syndrome and detection of microsatellite unstable (MSI) tumors eligible for immunotherapy. The aim of this study was to compare the relative diagnostic performance of three molecular MSI assays: polymerase chain r...

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Bibliographic Details
Main Authors: Franceska Dedeurwaerdere, Kathleen BM Claes, Jo Van Dorpe, Isabelle Rottiers, Joni Van der Meulen, Joke Breyne, Koen Swaerts, Geert Martens
Format: Article
Language:English
Published: Nature Publishing Group 2021-06-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-91974-x