Peptide-Based Selective Inhibitors of Matrix Metalloproteinase-Mediated Activities

Peptide-Based Selective Inhibitors of Matrix Metalloproteinase-Mediated Activities

The matrix metalloproteinases (MMPs) exhibit a broad array of activities, some catalytic and some non-catalytic in nature. An overall lack of selectivity has rendered small molecule, active site targeted MMP inhibitors problematic in execution. Inhibitors that favor few or individual members of the...

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Bibliographic Details
Main Authors: Margaret W. Ndinguri, Manishabrata Bhowmick, Dorota Tokmina-Roszyk, Trista K. Robichaud, Gregg B. Fields
Format: Article
Language:English
Published: MDPI AG 2012-11-01
Series:Molecules
Subjects:
matrix metalloproteinase
protease inhibitor
secondary binding site
cyclic peptide
phage display
triple-helix
Online Access:http://www.mdpi.com/1420-3049/17/12/14230

Internet

http://www.mdpi.com/1420-3049/17/12/14230

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