Dual Leucine Zipper Kinase Is Constitutively Active in the Adult Mouse Brain and Has Both Stress-Induced and Homeostatic Functions

Dual Leucine Zipper Kinase Is Constitutively Active in the Adult Mouse Brain and Has Both Stress-Induced and Homeostatic Functions

Dual leucine zipper kinase (DLK, Map3k12) is an axonal protein that governs the balance between degeneration and regeneration through its downstream effectors c-jun N-terminal kinase (JNK) and phosphorylated c-jun (p-c-Jun). In peripheral nerves DLK is generally inactive until induced by injury, aft...

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Bibliographic Details
Main Authors: Sunil Goodwani, Celia Fernandez, Paul J. Acton, Virginie Buggia-Prevot, Morgan L. McReynolds, Jiacheng Ma, Cheng Hui Hu, Mary E. Hamby, Yongying Jiang, Kang Le, Michael J. Soth, Philip Jones, William J. Ray
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:International Journal of Molecular Sciences
Subjects:
DLK
Map3k12
cerebellum
tau
synaptic maintenance
neurodegeneration
Online Access:https://www.mdpi.com/1422-0067/21/14/4849

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https://www.mdpi.com/1422-0067/21/14/4849

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