Abl family tyrosine kinases govern IgG extravasation in the skin in a murine pemphigus model

Abl family tyrosine kinases govern IgG extravasation in the skin in a murine pemphigus model

How antibody reaches tissues from circulation is critical for understanding antibody-mediated immunity. Here the authors show that IgG extravasation in the skin is mediated by endothelial caveolin transport independently of FcR, and is targetable by imatinib, which reduces IgG-dependent pathology in...

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Bibliographic Details
Main Authors: Sachiko Ono, Gyohei Egawa, Takashi Nomura, Akihiko Kitoh, Teruki Dainichi, Atsushi Otsuka, Saeko Nakajima, Masayuki Amagai, Fumi Matsumoto, Mami Yamamoto, Yoshiaki Kubota, Toshiyuki Takai, Tetsuya Honda, Kenji Kabashima
Format: Article
Language:English
Published: Nature Publishing Group 2019-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-12232-3

Internet

https://doi.org/10.1038/s41467-019-12232-3

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