Ligand modulation of sidechain dynamics in a wild-type human GPCR

Ligand modulation of sidechain dynamics in a wild-type human GPCR

GPCRs regulate all aspects of human physiology, and biophysical studies have deepened our understanding of GPCR conformational regulation by different ligands. Yet there is no experimental evidence for how sidechain dynamics control allosteric transitions between GPCR conformations. To address this...

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Bibliographic Details
Main Authors: Lindsay D Clark, Igor Dikiy, Karen Chapman, Karin EJ Rödström, James Aramini, Michael V LeVine, George Khelashvili, Søren GF Rasmussen, Kevin H Gardner, Daniel M Rosenbaum
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-10-01
Series:eLife
Subjects:
GPCR
NMR
dynamics
ligands
allostery
adenosine receptors
Online Access:https://elifesciences.org/articles/28505

Internet

https://elifesciences.org/articles/28505

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