Infection of Mycobacterium tuberculosis Promotes Both M1/M2 Polarization and MMP Production in Cigarette Smoke-Exposed Macrophages

Infection of Mycobacterium tuberculosis Promotes Both M1/M2 Polarization and MMP Production in Cigarette Smoke-Exposed Macrophages

Pulmonary tuberculosis (PTB) is a risk factor for COPD. Our previous study revealed more severe emphysema in COPD patients (mostly smokers) with prior tuberculosis. However, the mechanisms of interactions between cigarette smoke (CS) and Mycobacterium tuberculosis (Mtb) are unknown. In this study, w...

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Bibliographic Details
Main Authors: Yanqing Le, Wenli Cao, Lu Zhou, Xin Fan, Qiangui Liu, Fusheng Liu, Xiaoyan Gai, Chun Chang, Jing Xiong, Yafei Rao, Aling Li, Wei Xu, Beibei Liu, Tong Wang, Beinan Wang, Yongchang Sun
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Immunology
Subjects:
chronic obstructive pulmonary disease
cigarette smoke
Mycobacterium tuberculosis
macrophage polarization
matrix metalloproteinase
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.01902/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.01902/full

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