Tip cell-specific requirement for an atypical Gpr124- and Reck-dependent Wnt/β-catenin pathway during brain angiogenesis

Tip cell-specific requirement for an atypical Gpr124- and Reck-dependent Wnt/β-catenin pathway during brain angiogenesis

Despite the critical role of endothelial Wnt/β-catenin signaling during central nervous system (CNS) vascularization, how endothelial cells sense and respond to specific Wnt ligands and what aspects of the multistep process of intra-cerebral blood vessel morphogenesis are controlled by these angioge...

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Bibliographic Details
Main Authors: Benoit Vanhollebeke, Oliver A Stone, Naguissa Bostaille, Chris Cho, Yulian Zhou, Emilie Maquet, Anne Gauquier, Pauline Cabochette, Shigetomo Fukuhara, Naoki Mochizuki, Jeremy Nathans, Didier YR Stainier
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2015-06-01
Series:eLife
Subjects:
brain vascular development
tip cell
angiogenesis
Reck
Gpr124
Wnt7a/Wnt7b
Online Access:https://elifesciences.org/articles/06489

Internet

https://elifesciences.org/articles/06489

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