LEAP2 Impairs the Capability of the Growth Hormone Secretagogue Receptor to Regulate the Dopamine 2 Receptor Signaling

LEAP2 Impairs the Capability of the Growth Hormone Secretagogue Receptor to Regulate the Dopamine 2 Receptor Signaling

The growth hormone secretagogue receptor (GHSR) signals in response to ghrelin, but also acts via ligand-independent mechanisms that include either constitutive activation or interaction with other G protein-coupled receptors, such as the dopamine 2 receptor (D2R). A key target of GHSR in neurons is...

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Bibliographic Details
Main Authors: Emilio R. Mustafá, Santiago Cordisco González, Marjorie Damian, Sonia Cantel, Severine Denoyelle, Renaud Wagner, Helgi B. Schiöth, Jean-Alain Fehrentz, Jean-Louis Banères, Mario Perelló, Jesica Raingo
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Pharmacology
Subjects:
GPCR
heterodimerization
Cav2.2
ghrelin receptor
dopamine receptor
constitutive activity
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.712437/full

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https://www.frontiersin.org/articles/10.3389/fphar.2021.712437/full

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