Pepsin promotes IL-8 signaling-induced epithelial–mesenchymal transition in laryngeal carcinoma

Abstract Background Laryngopharyngeal reflux (LPR), with its increasing morbidity, is attracting considerable attention. In recent years, the causal role between LPR and laryngeal carcinoma has been debated. The main harmful component of LPR is pepsin, which has been shown to induce mucosal inflamma...

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Bibliographic Details
Main Authors: Jia-Jie Tan, Lu Wang, Ting-Ting Mo, Jie Wang, Mei-Gui Wang, Xiang-Ping Li
Format: Article
Language:English
Published: BMC 2019-03-01
Series:Cancer Cell International
Subjects:
Online Access:http://link.springer.com/article/10.1186/s12935-019-0772-7