Osthol Ameliorates Kidney Damage and Metabolic Syndrome Induced by a High-Fat/High-Sugar Diet

Osthol Ameliorates Kidney Damage and Metabolic Syndrome Induced by a High-Fat/High-Sugar Diet

Excessive intake of fructose results in metabolic syndrome (MS) and kidney damage, partly mediated by its metabolism by fructokinase-C or ketohexokinase-C (KHK-C). Osthol has antioxidant properties, is capable of regulating adipogenesis, and inhibits KHK-C activity. Here, we examined the potential p...

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Bibliographic Details
Main Authors: Fernando E. García-Arroyo, Guillermo Gonzaga-Sánchez, Edilia Tapia, Itzel Muñoz-Jiménez, Lino Manterola-Romero, Horacio Osorio-Alonso, Abraham S. Arellano-Buendía, José Pedraza-Chaverri, Carlos A. Roncal-Jiménez, Miguel A. Lanaspa, Richard J Johnson, Laura Gabriela Sánchez-Lozada
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:International Journal of Molecular Sciences
Subjects:
metabolic syndrome
renal lipotoxicity
fructokinase
coumarins
Online Access:https://www.mdpi.com/1422-0067/22/5/2431

Internet

https://www.mdpi.com/1422-0067/22/5/2431

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