Rolipram, a PDE4 Inhibitor, Enhances the Inotropic Effect of Rat Heart by Activating SERCA2a

Rolipram, a PDE4 Inhibitor, Enhances the Inotropic Effect of Rat Heart by Activating SERCA2a

This study was designed to investigate the hemodynamic effect of rolipram, a phosphodiesterase type 4 (PDE4) inhibitor, in normal rat hearts both in vivo and in vitro and its underlying mechanism. The pressure-volume loop, isolated heart, and Ca2+ transients triggered by field stimulation or caffein...

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Bibliographic Details
Main Authors: Huili Huang, Ming Xie, Li Gao, Wenhui Zhang, Xiaojia Zhu, Yuwei Wang, Wei Li, Rongrong Wang, Kesu Chen, Mohamed Boutjdir, Long Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Pharmacology
Subjects:
PDE4
rolipram
P-V loop
Ca2+ transient
SERCA2a
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.00221/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.00221/full

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