Discovery of proangiogenic CD44+mesenchymal cancer stem cells in an acute myeloid leukemia patient’s bone marrow

Discovery of proangiogenic CD44+mesenchymal cancer stem cells in an acute myeloid leukemia patient’s bone marrow

Abstract Here, we report a unique acute myeloid leukemia (AML) bone marrow-derived mesenchymal stem cell (MSC) with both mesenchymal and endothelial potential, which we have named Mesenchymal Cancer Stem Cells (MCSCs). These MCSCs are CD90-CD13-CD44+ and differ from MSCs in isolation, expansion, dif...

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Bibliographic Details
Main Authors: Huynh Cao, Jeffrey Xiao, Mark E. Reeves, Kimberly Payne, Chien Shing Chen, David J. Baylink, Guido Marcucci, Yi Xu
Format: Article
Language:English
Published: BMC 2020-06-01
Series:Journal of Hematology & Oncology
Subjects:
Acute myeloid leukemia
Mesenchymal stem cells
Mesenchymal cancer stem cells
CD44
Angiogenesis
Microenvironment
Online Access:http://link.springer.com/article/10.1186/s13045-020-00899-x

Internet

http://link.springer.com/article/10.1186/s13045-020-00899-x

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