Premature Activation of Immune Transcription Programs in Autoimmune-Predisposed Mouse Embryonic Stem Cells and Blastocysts

Premature Activation of Immune Transcription Programs in Autoimmune-Predisposed Mouse Embryonic Stem Cells and Blastocysts

Autoimmune diabetes is a complex multifactorial disease with genetic and environmental factors playing pivotal roles. While many genes associated with the risk of diabetes have been identified to date, the mechanisms by which external triggers contribute to the genetic predisposition remain unclear....

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Bibliographic Details
Main Authors: Oktay Kirak, Eugene Ke, Kevin Y. Yang, Anna Schwarz, Lars Plate, Amy Nham, Justin R. Abadejos, Anna Valencia, R. Luke Wiseman, Kathy O. Lui, Manching Ku
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:International Journal of Molecular Sciences
Subjects:
embryonic stem cells
autoimmunity
non-obese diabetic mice
predisposition
RNA-Seq
ChIP-Seq
Online Access:https://www.mdpi.com/1422-0067/21/16/5743

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https://www.mdpi.com/1422-0067/21/16/5743

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