Identification of functional regulatory elements in the human genome using pooled CRISPR screens

Abstract Background Genome-scale pooled CRISPR screens are powerful tools for identifying genetic dependencies across varied cellular processes. The vast majority of CRISPR screens reported to date have focused exclusively on the perturbation of protein-coding gene function. However, protein-coding...

Full description

Bibliographic Details
Main Authors: Samantha M. Borys, Scott T. Younger
Format: Article
Language:English
Published: BMC 2020-01-01
Series:BMC Genomics
Subjects:
p53
Online Access:https://doi.org/10.1186/s12864-020-6497-0