CircMYH9 drives colorectal cancer growth by regulating serine metabolism and redox homeostasis in a p53-dependent manner

CircMYH9 drives colorectal cancer growth by regulating serine metabolism and redox homeostasis in a p53-dependent manner

Abstract Background Circular RNAs (circRNAs) play important roles in cancer progression and metabolism regulation. Serine/glycine metabolism supports the growth of cancer cells by contributing to their anabolic demands and epigenome as well as by regulating their redox state. However, the role of ci...

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Bibliographic Details
Main Authors: Xin Liu, Yunze Liu, Zhao Liu, Changwei Lin, Fanchao Meng, Lei Xu, Xiuzhong Zhang, Chong Zhang, Penbo Zhang, Shuai Gong, Nai Wu, Zeqiang Ren, Jun Song, Yi Zhang
Format: Article
Language:English
Published: BMC 2021-09-01
Series:Molecular Cancer
Subjects:
circMYH9
p53
Colorectal cancer
Serine/glycine metabolism
Redox homeostasis
Online Access:https://doi.org/10.1186/s12943-021-01412-9

Internet

https://doi.org/10.1186/s12943-021-01412-9

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