The flavones apigenin and luteolin induce FOXO1 translocation but inhibit gluconeogenic and lipogenic gene expression in human cells.

The flavones apigenin and luteolin induce FOXO1 translocation but inhibit gluconeogenic and lipogenic gene expression in human cells.

The flavones apigenin (4',5,7,-trihydroxyflavone) and luteolin (3',4',5,7,-tetrahydroxyflavone) are plant secondary metabolites with antioxidant, antiinflammatory, and anticancer activities. We evaluated their impact on cell signaling pathways related to insulin-resistance and type 2...

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Bibliographic Details
Main Authors: Christiane Bumke-Vogt, Martin A Osterhoff, Andrea Borchert, Valentina Guzman-Perez, Zeinab Sarem, Andreas L Birkenfeld, Volker Bähr, Andreas F H Pfeiffer
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4138109?pdf=render

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http://europepmc.org/articles/PMC4138109?pdf=render

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