Comparison of Various Chromatographic Systems for Analysis of Cytisine in Human Serum, Saliva and Pharmaceutical Formulation by HPLC with Diode Array, Fluorescence or Mass Spectrometry Detection

Comparison of Various Chromatographic Systems for Analysis of Cytisine in Human Serum, Saliva and Pharmaceutical Formulation by HPLC with Diode Array, Fluorescence or Mass Spectrometry Detection

<i>Background:</i> Identification and quantitative determination of cytisine, especially in biological samples and pharmaceutical formulations, is still a difficult analytical task. Cytisine is an alkaloid with a small and very polar molecule. For this reason, it is very weakly retained...

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Bibliographic Details
Main Authors: Karol Wróblewski, Anna Petruczynik, Tomasz Tuzimski, Dominika Przygodzka, Grzegorz Buszewicz, Patrycjusz Kołodziejczyk, Piotr Tutka
Format: Article
Language:English
Published: MDPI AG 2019-07-01
Series:Molecules
Subjects:
cytisine
HPLC-DAD
HPLC-FLD
HPLC-MS/MS
SPE
optimisation of chromatographic systems
serum
saliva
pharmaceutical preparation
retention mechanism
Online Access:https://www.mdpi.com/1420-3049/24/14/2580

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https://www.mdpi.com/1420-3049/24/14/2580

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