Synthetic carbohydrate-based vaccines: challenges and opportunities
Abstract Glycoconjugate vaccines based on bacterial capsular polysaccharides (CPS) have been extremely successful in preventing bacterial infections. The glycan antigens for the preparation of CPS based glycoconjugate vaccines are mainly obtained from bacterial fermentation, the quality and length o...
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doaj-0e8d4ec1fa224e0586b21ad5c7a09aa72021-01-03T12:11:24ZengBMCJournal of Biomedical Science1423-01272020-01-0127112210.1186/s12929-019-0591-0Synthetic carbohydrate-based vaccines: challenges and opportunitiesRavinder Mettu0Chiang-Yun Chen1Chung-Yi Wu2Genomics Research Center, Academia SinicaGenomics Research Center, Academia SinicaGenomics Research Center, Academia SinicaAbstract Glycoconjugate vaccines based on bacterial capsular polysaccharides (CPS) have been extremely successful in preventing bacterial infections. The glycan antigens for the preparation of CPS based glycoconjugate vaccines are mainly obtained from bacterial fermentation, the quality and length of glycans are always inconsistent. Such kind of situation make the CMC of glycoconjugate vaccines are difficult to well control. Thanks to the advantage of synthetic methods for carbohydrates syntheses. The well controlled glycan antigens are more easily to obtain, and them are conjugated to carrier protein to from the so-call homogeneous fully synthetic glycoconjugate vaccines. Several fully glycoconjugate vaccines are in different phases of clinical trial for bacteria or cancers. The review will introduce the recent development of fully synthetic glycoconjugate vaccine.https://doi.org/10.1186/s12929-019-0591-0CarbohydratesImmunogenicityAntigenicityPolysaccharidesVaccines and Cancer |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ravinder Mettu Chiang-Yun Chen Chung-Yi Wu |
spellingShingle |
Ravinder Mettu Chiang-Yun Chen Chung-Yi Wu Synthetic carbohydrate-based vaccines: challenges and opportunities Journal of Biomedical Science Carbohydrates Immunogenicity Antigenicity Polysaccharides Vaccines and Cancer |
author_facet |
Ravinder Mettu Chiang-Yun Chen Chung-Yi Wu |
author_sort |
Ravinder Mettu |
title |
Synthetic carbohydrate-based vaccines: challenges and opportunities |
title_short |
Synthetic carbohydrate-based vaccines: challenges and opportunities |
title_full |
Synthetic carbohydrate-based vaccines: challenges and opportunities |
title_fullStr |
Synthetic carbohydrate-based vaccines: challenges and opportunities |
title_full_unstemmed |
Synthetic carbohydrate-based vaccines: challenges and opportunities |
title_sort |
synthetic carbohydrate-based vaccines: challenges and opportunities |
publisher |
BMC |
series |
Journal of Biomedical Science |
issn |
1423-0127 |
publishDate |
2020-01-01 |
description |
Abstract Glycoconjugate vaccines based on bacterial capsular polysaccharides (CPS) have been extremely successful in preventing bacterial infections. The glycan antigens for the preparation of CPS based glycoconjugate vaccines are mainly obtained from bacterial fermentation, the quality and length of glycans are always inconsistent. Such kind of situation make the CMC of glycoconjugate vaccines are difficult to well control. Thanks to the advantage of synthetic methods for carbohydrates syntheses. The well controlled glycan antigens are more easily to obtain, and them are conjugated to carrier protein to from the so-call homogeneous fully synthetic glycoconjugate vaccines. Several fully glycoconjugate vaccines are in different phases of clinical trial for bacteria or cancers. The review will introduce the recent development of fully synthetic glycoconjugate vaccine. |
topic |
Carbohydrates Immunogenicity Antigenicity Polysaccharides Vaccines and Cancer |
url |
https://doi.org/10.1186/s12929-019-0591-0 |
work_keys_str_mv |
AT ravindermettu syntheticcarbohydratebasedvaccineschallengesandopportunities AT chiangyunchen syntheticcarbohydratebasedvaccineschallengesandopportunities AT chungyiwu syntheticcarbohydratebasedvaccineschallengesandopportunities |
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1724350667810668544 |