MtrA Response Regulator Controls Cell Division and Cell Wall Metabolism and Affects Susceptibility of Mycobacteria to the First Line Antituberculosis Drugs

The biological processes regulated by the essential response regulator MtrA and the growth conditions promoting its activation in Mycobacterium tuberculosis, a slow grower and pathogen, are largely unknown. Here, using a gain-of-function mutant, MtrAY 102C, which functions in the absence of the cogn...

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Bibliographic Details
Main Authors: Purushotham Gorla, Renata Plocinska, Krishna Sarva, Akash T. Satsangi, Emmanuel Pandeeti, Robert Donnelly, Jaroslaw Dziadek, Malini Rajagopalan, Murty V. Madiraju
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Microbiology
Subjects:
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2018.02839/full