MtrA Response Regulator Controls Cell Division and Cell Wall Metabolism and Affects Susceptibility of Mycobacteria to the First Line Antituberculosis Drugs
The biological processes regulated by the essential response regulator MtrA and the growth conditions promoting its activation in Mycobacterium tuberculosis, a slow grower and pathogen, are largely unknown. Here, using a gain-of-function mutant, MtrAY 102C, which functions in the absence of the cogn...
Main Authors: | Purushotham Gorla, Renata Plocinska, Krishna Sarva, Akash T. Satsangi, Emmanuel Pandeeti, Robert Donnelly, Jaroslaw Dziadek, Malini Rajagopalan, Murty V. Madiraju |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2018-11-01
|
Series: | Frontiers in Microbiology |
Subjects: | |
Online Access: | https://www.frontiersin.org/article/10.3389/fmicb.2018.02839/full |
Similar Items
-
Deletion of MtrA Inhibits Cellular Development of Streptomyces coelicolor and Alters Expression of Developmental Regulatory Genes
by: Peipei Zhang, et al.
Published: (2017-10-01) -
The Conserved Actinobacterial Two-Component System MtrAB Coordinates Chloramphenicol Production with Sporulation in Streptomyces venezuelae NRRL B-65442
by: Nicolle F. Som, et al.
Published: (2017-06-01) -
Development of a Hyperosmotic Stress Inducible Gene Expression System by Engineering the MtrA/MtrB-Dependent NCgl1418 Promoter in Corynebacterium glutamicum
by: Jingwen Huang, et al.
Published: (2021-07-01) -
Die Integration eines computerbasierten Anatomie-Lernprogramms im Curriculum der Ausbildung Medizinisch-technischer Assistenten der Fachrichtung Radiologie [The integration of a computer-based tutorial in anatomy into an educational curriculum for student radiographers/technicians]
by: Niewald, Marcus, et al.
Published: (2009-11-01) -
Dynamic Analysis on the Safety Criteria of the Conceptual Core Design in MTR-type Research Reactor
by: T. Surbakti, et al.
Published: (2018-08-01)