Trib1 Is Overexpressed in Systemic Lupus Erythematosus, While It Regulates Immunoglobulin Production in Murine B Cells

Trib1 Is Overexpressed in Systemic Lupus Erythematosus, While It Regulates Immunoglobulin Production in Murine B Cells

Systemic lupus erythematosus (SLE) is a severe and heterogeneous autoimmune disease with a complex genetic etiology, characterized by the production of various pathogenic autoantibodies, which participate in end-organ damages. The majority of human SLE occurs in adults as a polygenic disease, and cl...

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Bibliographic Details
Main Authors: Léa Simoni, Virginia Delgado, Julie Ruer-Laventie, Delphine Bouis, Anne Soley, Vincent Heyer, Isabelle Robert, Vincent Gies, Thierry Martin, Anne-Sophie Korganow, Bernardo Reina San Martin, Pauline Soulas-Sprauel
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-03-01
Series:Frontiers in Immunology
Subjects:
lupus
B cells
Trib1
mouse model
Ig secretion
negative regulator
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00373/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2018.00373/full

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