TNF inhibits Notch-1 in skeletal muscle cells by Ezh2 and DNA methylation mediated repression: implications in duchenne muscular dystrophy.

TNF inhibits Notch-1 in skeletal muscle cells by Ezh2 and DNA methylation mediated repression: implications in duchenne muscular dystrophy.

Classical NF-kappaB signaling functions as a negative regulator of skeletal myogenesis through potentially multiple mechanisms. The inhibitory actions of TNFalpha on skeletal muscle differentiation are mediated in part through sustained NF-kappaB activity. In dystrophic muscles, NF-kappaB activity i...

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Bibliographic Details
Main Authors: Swarnali Acharyya, Sudarshana M Sharma, Alfred S Cheng, Katherine J Ladner, Wei He, William Kline, Huating Wang, Michael C Ostrowski, Tim H Huang, Denis C Guttridge
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-08-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2930001?pdf=render

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http://europepmc.org/articles/PMC2930001?pdf=render

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