Chronopharmacokinetics of Methotrexate in Mice: Modulation by Administration of 5-Fluorouracil in Combination Chemotherapy
The basic pharmacokinetic parameters of MTX administered as monotherapy as well as in the combined therapy with simultaneous and prior administation of FU were investigated. The parameters were determined in the two-compartment open system on the basis of measurement of MTX levels in mice after i.p....
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| Format: | Article |
| Language: | English |
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De Gruyter
1996-08-01
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| Series: | Pteridines |
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| Online Access: | https://doi.org/10.1515/pteridines.1996.7.3.77 |