Cross-Linking Effects Dictate the Preference of Galectins to Bind LacNAc-Decorated HPMA Copolymers

Cross-Linking Effects Dictate the Preference of Galectins to Bind LacNAc-Decorated HPMA Copolymers

The interaction of multi-LacNAc (Galβ1-4GlcNAc)-containing <i>N</i>-(2-hydroxypropyl) methacrylamide (HPMA) copolymers with human galectin-1 (Gal-1) and the carbohydrate recognition domain (CRD) of human galectin-3 (Gal-3) was analyzed using NMR methods in addition to cryo-electron-micro...

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Bibliographic Details
Main Authors: Sara Bertuzzi, Ana Gimeno, Ane Martinez-Castillo, Marta G. Lete, Sandra Delgado, Cristina Airoldi, Marina Rodrigues Tavares, Markéta Bláhová, Petr Chytil, Vladimír Křen, Nicola G. A. Abrescia, Ana Ardá, Pavla Bojarová, Jesús Jiménez-Barbero
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:International Journal of Molecular Sciences
Subjects:
galectin
multivalency
glycomimetic
molecular recognition
HPMA copolymer
inhibition
Online Access:https://www.mdpi.com/1422-0067/22/11/6000

Internet

https://www.mdpi.com/1422-0067/22/11/6000

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