Cell Biological Mechanisms of Activity-Dependent Synapse to Nucleus Translocation of CRTC1 in Neurons

Cell Biological Mechanisms of Activity-Dependent Synapse to Nucleus Translocation of CRTC1 in Neurons

Previous studies have revealed a critical role for CREB-regulated transcriptional coactivator (CRTC1) in regulating neuronal gene expression during learning and memory. CRTC1 localizes to synapses but undergoes activity-dependent nuclear translocation to regulate the transcription of CREB target gen...

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Bibliographic Details
Main Authors: Toh Hean eCh'ng, Martina eDeSalvo, Peter eLin, Ajay eVashisht, James eWohlschlegel, Kelsey eMartin
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-09-01
Series:Frontiers in Molecular Neuroscience
Subjects:
synaptic plasticity
CREB
learning and memory
CRTC1
synapse to nucleus signaling
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnmol.2015.00048/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnmol.2015.00048/full

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