Single-cell RNA-sequencing reveals transcriptional dynamics of estrogen-induced dysplasia in the ovarian surface epithelium.

Single-cell RNA-sequencing reveals transcriptional dynamics of estrogen-induced dysplasia in the ovarian surface epithelium.

Estrogen therapy increases the risk of ovarian cancer and exogenous estradiol accelerates the onset of ovarian cancer in mouse models. Both in vivo and in vitro, ovarian surface epithelial (OSE) cells exposed to estradiol develop a subpopulation that loses cell polarity, contact inhibition, and form...

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Bibliographic Details
Main Authors: Nhung H Vuong, David P Cook, Laura A Forrest, Lauren E Carter, Pascale Robineau-Charette, Joshua M Kofsky, Kendra M Hodgkinson, Barbara C Vanderhyden
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-11-01
Series:PLoS Genetics
Online Access:https://doi.org/10.1371/journal.pgen.1007788

Internet

https://doi.org/10.1371/journal.pgen.1007788

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