FGF-2b and h-PL Transform Duct and Non-Endocrine Human Pancreatic Cells into Endocrine Insulin Secreting Cells by Modulating Differentiating Genes

FGF-2b and h-PL Transform Duct and Non-Endocrine Human Pancreatic Cells into Endocrine Insulin Secreting Cells by Modulating Differentiating Genes

Background: Diabetes mellitus (DM) is a multifactorial disease orphan of a cure. Regenerative medicine has been proposed as novel strategy for DM therapy. Human fibroblast growth factor (FGF)-2b controls β-cell clusters via autocrine action, and human placental lactogen (hPL)-A increases functional...

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Bibliographic Details
Main Authors: Giulia Donadel, Donatella Pastore, David Della-Morte, Barbara Capuani, Marco F. Lombardo, Francesca Pacifici, Marco Bugliani, Fabio A. Grieco, Piero Marchetti, Davide Lauro
Format: Article
Language:English
Published: MDPI AG 2017-10-01
Series:International Journal of Molecular Sciences
Subjects:
pancreatic β cells
cellular differentiation
insulin release
regenerative medicine
diabetes mellitus
Online Access:https://www.mdpi.com/1422-0067/18/11/2234

Internet

https://www.mdpi.com/1422-0067/18/11/2234

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