Differential 3’ processing of specific transcripts expands regulatory and protein diversity across neuronal cell types

Differential 3’ processing of specific transcripts expands regulatory and protein diversity across neuronal cell types

Alternative polyadenylation (APA) regulates mRNA translation, stability, and protein localization. However, it is unclear to what extent APA regulates these processes uniquely in specific cell types. Using a new technique, cTag-PAPERCLIP, we discovered significant differences in APA between the prin...

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Bibliographic Details
Main Authors: Saša Jereb, Hun-Way Hwang, Eric Van Otterloo, Eve-Ellen Govek, John J Fak, Yuan Yuan, Mary E Hatten, Robert B Darnell
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-03-01
Series:eLife
Subjects:
alternative polyadenylation
cerebellum
Purkinje cells
granule cells
Online Access:https://elifesciences.org/articles/34042

Internet

https://elifesciences.org/articles/34042

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