APP Maturation and Intracellular Localization Are Controlled by a Specific Inhibitor of 37/67 kDa Laminin-1 Receptor in Neuronal Cells

APP Maturation and Intracellular Localization Are Controlled by a Specific Inhibitor of 37/67 kDa Laminin-1 Receptor in Neuronal Cells

Amyloid precursor protein (APP) is processed along both the nonamyloidogenic pathway preventing amyloid beta peptide (Aβ) production and the amyloidogenic pathway, generating Aβ, whose accumulation characterizes Alzheimer’s disease. Items of evidence report that the intra...

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Bibliographic Details
Main Authors: Antaripa Bhattacharya, Adriana Limone, Filomena Napolitano, Carmen Cerchia, Silvia Parisi, Giuseppina Minopoli, Nunzia Montuori, Antonio Lavecchia, Daniela Sarnataro
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:International Journal of Molecular Sciences
Subjects:
amyloid precursor protein (app)
intracellular trafficking
37/67 kda laminin receptor
prion
posttranslational modifications
small molecule inhibitors
Online Access:https://www.mdpi.com/1422-0067/21/5/1738

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https://www.mdpi.com/1422-0067/21/5/1738

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