Baoyuan Jiedu Decoction Alleviates Cancer-Induced Myotube Atrophy by Regulating Mitochondrial Dynamics Through p38 MAPK/PGC-1α Signaling Pathway

Baoyuan Jiedu Decoction Alleviates Cancer-Induced Myotube Atrophy by Regulating Mitochondrial Dynamics Through p38 MAPK/PGC-1α Signaling Pathway

Cancer cachexia is a multifactorial syndrome characterized by continuous body wasting and loss of skeletal muscle. Impaired mitochondria function is closely associated with muscle atrophy in cancer cachexia. Our previous study confirmed the effectiveness of Baoyuan Jiedu decoction (BJD) in inhibitin...

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Bibliographic Details
Main Authors: Delong Wang, Weiqiao Chen, Qianyu Bi, Xin Zong, Jiazhao Ruan, Xiangjun Yin, Jixin Wang, Honghua Zhang, Xuming Ji
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Oncology
Subjects:
cancer cachexia
Baoyuan Jiedu decoction (BJD)
traditional Chinese medicine
mitochondrial dynamics
p38 MAPK/PGC-1α pathway
in vitro
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.523577/full

Internet

https://www.frontiersin.org/article/10.3389/fonc.2020.523577/full

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