Structural and mechanistic insights into ATRX-dependent and -independent functions of the histone chaperone DAXX

Structural and mechanistic insights into ATRX-dependent and -independent functions of the histone chaperone DAXX

The ATRX-DAXX histone chaperone complex incorporates H3.3 in heterochromatin in a replication-independent manner. Here, the authors present a high-resolution x-ray crystal structure of an interaction surface between ATRX and DAXX, and characterize ATRX-dependent and-independent functions of DAXX.

Bibliographic Details
Main Authors: Dominik Hoelper, Hongda Huang, Aayushi Y. Jain, Dinshaw J. Patel, Peter W. Lewis
Format: Article
Language:English
Published: Nature Publishing Group 2017-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-01206-y

Internet

https://doi.org/10.1038/s41467-017-01206-y

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